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Quercetin suppresses the metastatic ability of lung cancer through inhibiting Snail-dependent Akt activation and Snail-independent ADAM9 expression pathways.
- Source :
-
BBA - Molecular Cell Research . Oct2017, Vol. 1864 Issue 10, p1746-1758. 13p. - Publication Year :
- 2017
-
Abstract
- Metastasis is the major cause of death from lung cancer. Quercetin, a widely distributed bioflavonoid, is well known to induce growth inhibition in a variety of human cancer cells, but how it affects lung cancer cell invasion and metastasis is unclear. Herein, we found that quercetin inhibited the migration/invasion of non-small cell lung cancer (NSCLC) cell lines and bone metastasis in an orthotopic A549 xenograft model by suppressing the Snail-mediated epithelial-to-mesenchymal transition (EMT). Moreover, survival times of animals were also prolonged after quercetin treatment. Mechanistic investigations found that quercetin suppressed Snail-dependent Akt activation by upregulating maspin and Snail-independent a disintegrin and metalloproteinase (ADAM) 9 expression pathways to modulate the invasive ability of NSCLC cells. In clinical samples, we observed that patients with Snail high /p-Akt high tumors had the shortest survival times. In addition, a lower survival rate was also found in ADAM9 high patients than in ADAM9 low patients. Overall, our results provide new insights into the role of quercetin-induced molecular regulation in suppressing NSCLC metastasis and suggest that quercetin has potential therapeutic applications for metastatic NSCLC. [ABSTRACT FROM AUTHOR]
- Subjects :
- *QUERCETIN
*LUNG cancer
*METASTASIS
*NON-small-cell lung carcinoma
*PHOSPHORYLATION
Subjects
Details
- Language :
- English
- ISSN :
- 01674889
- Volume :
- 1864
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- BBA - Molecular Cell Research
- Publication Type :
- Academic Journal
- Accession number :
- 124877772
- Full Text :
- https://doi.org/10.1016/j.bbamcr.2017.06.017