Back to Search
Start Over
Crystal Structure of a Plant Multidrug and Toxic Compound Extrusion Family Protein.
- Source :
-
Structure . Sep2017, Vol. 25 Issue 9, p1455-1460.e2. 1p. - Publication Year :
- 2017
-
Abstract
- Summary The multidrug and toxic compound extrusion (MATE) family of proteins consists of transporters responsible for multidrug resistance in prokaryotes. In plants, a number of MATE proteins were identified by recent genomic and functional studies, which imply that the proteins have substrate-specific transport functions instead of multidrug extrusion. The three-dimensional structure of eukaryotic MATE proteins, including those of plants, has not been reported, preventing a better understanding of the molecular mechanism of these proteins. Here, we describe the crystal structure of a MATE protein from the plant Camelina sativa at 2.9 Å resolution. Two sets of six transmembrane α helices, assembled pseudo-symmetrically, possess a negatively charged internal pocket with an outward-facing shape. The crystal structure provides insight into the diversity of plant MATE proteins and their substrate recognition and transport through the membrane. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09692126
- Volume :
- 25
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Structure
- Publication Type :
- Academic Journal
- Accession number :
- 124936842
- Full Text :
- https://doi.org/10.1016/j.str.2017.07.009