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A review of high performance liquid chromatographic-mass spectrometric urinary methods for anticancer drug exposure of health care workers.

Authors :
Mathias, Patricia I.
Connor, Thomas H.
B'hymer, Clayton
Source :
Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences. Aug2017, Vol. 1060, p316-324. 9p.
Publication Year :
2017

Abstract

This review describes published high performance liquid chromatography/mass spectrometry (HPLC–MS) methods for the determination of anticancer drugs in human urine as non-invasive tool for monitoring of health care worker exposure to antineoplastic and cytotoxic drugs. HPLC–MS is a sensitive and specific method for analysis of anticancer drugs and their metabolites in biological fluids. In this review, a tabular summary and overview of published HPLC–MS methods are presented, as well as future trends and limitations in this area of research. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
15700232
Volume :
1060
Database :
Academic Search Index
Journal :
Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
Publication Type :
Academic Journal
Accession number :
124953669
Full Text :
https://doi.org/10.1016/j.jchromb.2017.06.028