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Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
- Source :
-
Plant Physiology . Sep2017, Vol. 175 Issue 1, p303-313. 11p. - Publication Year :
- 2017
-
Abstract
- The endocycle represents a modified mitotic cell cycle that in plants is often coupled to cell enlargement and differentiation. Endocycle onset is controlled by activity of the Anaphase Promoting Complex/Cyclosome (APC/C), a multisubunit E3 ubiquitin ligase targeting cell-cycle factors for destruction. CELL CYCLE SWITCH52 (CCS52) proteins represent rate-limiting activator subunits of the APC/C. In Arabidopsis (Arabidopsis thaliana), mutations in either CCS52A1 or CCS52A2 activators result in a delayed endocycle onset, whereas their overexpression triggers increased DNA ploidy levels. Here, the relative contribution of the APC/CCCS52A1 and APC/CCCS52A2 complexes to different developmental processes was studied through analysis of their negative regulators, being the ULTRAVIOLET-B-INSENSITIVE4 protein and the DP-E2F-Like1 transcriptional repressor, respectively. Our data illustrate cooperative activity of the APC/CCCS52A1 and APC/CCCS52A2 complexes during root and trichome development, but functional interdependency during leaf development. Furthermore, we found APC/CCCS52A1 activity to control CCS52A2 expression. We conclude that interdependency of CCS52A-controlled APC/C activity is controlled in a tissue-specific manner. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00320889
- Volume :
- 175
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Plant Physiology
- Publication Type :
- Academic Journal
- Accession number :
- 124960990
- Full Text :
- https://doi.org/10.1104/pp.17.00785