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Synthesis of Tribenzo[b,e,g]phosphindole Oxides via Radical Bicyclization Cascades of o-Arylalkynylanilines.
- Source :
-
Organic Letters . Sep2017, Vol. 19 Issue 17, p4512-4515. 4p. - Publication Year :
- 2017
-
Abstract
- A new DTBP/Mg(NO3)2-mediated bicyclization cascade of o-arylalkynylanilines with secondary arylphosphine oxides has been developed, enabling dual C(sp2)-H functionalization along with the cleavage of the C-N bond. The combination between regioselective P-centered radical-triggered [3 + 2] cyclization and C-centered radical-induced cross-coupling in a one-pot manner delivered 27 examples of tribenzo[b,e,g]phosphindole oxides with generally high regioselectivity. A reasonable mechanism for forming such products involving radical addition-cyclization cascade is proposed. [ABSTRACT FROM AUTHOR]
- Subjects :
- *OXYGEN compounds
*CHEMICALS
*OXIDES
*CARBON
*BICYCLIC compounds
*INDOLE compounds
Subjects
Details
- Language :
- English
- ISSN :
- 15237060
- Volume :
- 19
- Issue :
- 17
- Database :
- Academic Search Index
- Journal :
- Organic Letters
- Publication Type :
- Academic Journal
- Accession number :
- 124966642
- Full Text :
- https://doi.org/10.1021/acs.orglett.7b02071