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Transition-Metal-Free One-Pot Tandem Synthesis of 4-Quinolone and 4H-Thiochromen-4-one Derivatives Through Sequential Nucleophilic Addition-Elimination-SNAr Reaction.
- Source :
-
Synthesis . 2017, Vol. 49 Issue 18, p4309-4320. 12p. - Publication Year :
- 2017
-
Abstract
- 4-Quinolone and 4H-thiochromen-4-one derivatives are readily synthesized in a tandem one-pot manner in good to excellent yields. Starting from (Z)-β-chlorovinyl ketones, an intermolecular nucleophilic addition of amines or sodium hydrogen sulfide to (Z)-β-chlorovinyl ketones was followed by elimination of chlorine anion to give Z-enamine or thioenol intermediates, which can be transformed to 4-quinolone or 4H-thiochromen-4-one products through intramolecular SNAr reaction, respectively. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00397881
- Volume :
- 49
- Issue :
- 18
- Database :
- Academic Search Index
- Journal :
- Synthesis
- Publication Type :
- Academic Journal
- Accession number :
- 125014613
- Full Text :
- https://doi.org/10.1055/s-0036-1588466