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Serotonin transporter immunoreactivity is modulated during development and after fluoxetine treatment in the rodent visual system.

Authors :
Rodrigues Junior, Wandilson dos Santos
Oliveira-Silva, Priscilla
Faria-Melibeu, Adriana da Cunha
Campello-Costa, Paula
Serfaty, Claudio Alberto
Source :
Neuroscience Letters. Sep2017, Vol. 657, p38-44. 7p.
Publication Year :
2017

Abstract

The serotonin transporter (5-HTT) regulates serotonin homeostasis and has been used as a target for different drugs in depression treatment. Although the serotonergic system has received a lot of attention, little is known about the effects of these drugs over serotonin transporters. In this work, we investigated the expression pattern of 5-HTT during development of the visual system and the influence of fluoxetine on different signaling pathways. Our data showed that the expression of 5-HTT has a gradual increase from postnatal day 0 until 42 and decrease afterwards. Moreover, chronic fluoxetine treatment both in childhood and adolescence induces down regulation of 5-HTT expression and phosphorylation of ERK and AKT signaling pathways. Together these data suggest that the levels of 5-HTT protein could be important for the development of the central nervous system and suggest that the ERK and AKT are involved in the molecular pathways of antidepressants drugs, acting in concert to improve serotonergic signaling. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
03043940
Volume :
657
Database :
Academic Search Index
Journal :
Neuroscience Letters
Publication Type :
Academic Journal
Accession number :
125022324
Full Text :
https://doi.org/10.1016/j.neulet.2017.07.047