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Psychiatric behaviors associated with cytoskeletal defects in radial neuronal migration.

Authors :
Fukuda, Toshifumi
Yanagi, Shigeru
Source :
Cellular & Molecular Life Sciences. Oct2017, Vol. 74 Issue 19, p3533-3552. 20p.
Publication Year :
2017

Abstract

Normal development of the cerebral cortex is an important process for higher brain functions, such as language, and cognitive and social functions. Psychiatric disorders, such as schizophrenia and autism, are thought to develop owing to various dysfunctions occurring during the development of the cerebral cortex. Radial neuronal migration in the embryonic cerebral cortex is a complex process, which is achieved by strict control of cytoskeletal dynamics, and impairments in this process are suggested to cause various psychiatric disorders. Our recent findings indicate that radial neuronal migration as well as psychiatric behaviors is rescued by controlling microtubule stability during the embryonic stage. In this review, we outline the relationship between psychiatric disorders, such as schizophrenia and autism, and radial neuronal migration in the cerebral cortex by focusing on the cytoskeleton and centrosomes. New treatment strategies for psychiatric disorders will be discussed. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
1420682X
Volume :
74
Issue :
19
Database :
Academic Search Index
Journal :
Cellular & Molecular Life Sciences
Publication Type :
Academic Journal
Accession number :
125025924
Full Text :
https://doi.org/10.1007/s00018-017-2539-4