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Copy number variations of the IL-22 gene are associated with ankylosing spondylitis: A case-control study in Chinese Han population.
- Source :
-
Human Immunology . Sep2017, Vol. 78 Issue 9, p547-552. 6p. - Publication Year :
- 2017
-
Abstract
- IL-22 provides a new insight into the mechanisms of autoimmunity, and copy number variations (CNVs) are associated with autoimmune diseases. This study aims to explore the association of IL-22 gene CNVs with ankylosing spondylitis (AS) susceptibility. The copy numbers of IL-22 gene (2 fragments: IL-22_1, IL-22_2) were examined by AccuCopyâ„¢ methods in a cohort of 649 AS patients and 628 controls. Association of IL-22 CNVs and AS susceptibility was analyzed, and AS risk was estimated by Odds Ratio (ORs) and 95% confidence intervals (CIs), and the Benjamini-Hochberg method was applied to regulate the false discovery rate (FDR). We found one copy of IL-22 gene was significantly associated with AS [OR = 0.345, 95%CI (0.144, 0.827), P = 0.013, P FDR = 0.026] in the IL-22_2 fragment, and this association still exist after adjustment of age and sex [OR = 0.344, 95%CI (0.143, 0.825), P = 0.017, P FDR = 0.034]. In the stratification analysis by gender, the statistical difference was detected in males in the IL-22_2 fragment [OR = 0.306, 95%CI (0.121, 0.778), P = 0.009, P FDR = 0.018; adjusted OR = 0.306, 95%CI (0.120, 0.777), P = 0.013, P FDR = 0.026]. We suggest that IL-22 CNVs are associated with AS and that lower copy number might be a protective factor for AS, especially in male patients. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01988859
- Volume :
- 78
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Human Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 125058099
- Full Text :
- https://doi.org/10.1016/j.humimm.2017.07.006