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Melanocortin neurons: Multiple routes to regulation of metabolism.

Authors :
Shen, Wen-jie
Yao, Ting
Kong, Xingxing
Williams, Kevin W.
Liu, Tiemin
Source :
BBA: Molecular Basis of Disease. Oct2017 Part A, Vol. 1863 Issue 10A, p2477-2485. 9p.
Publication Year :
2017

Abstract

The burden of disability, premature death, escalating health care costs and lost economic productivity due to obesity and its associated complications including hypertension, stroke, cardiovascular disease and type 2 diabetes is staggering [1,2] . A better understanding of metabolic homeostatic pathways will provide us with insights into the biological mechanisms of obesity and how to fundamentally address this epidemic [3–6] . In mammals, energy balance is maintained via a homeostatic system involving both peripheral and central melanocortin systems; changes in body weight reflect an unbalance of the energetic state [7–9] . Although the primary cause of obesity is unknown, there is significant effort to understand the role of the central melanocortin pathway in the brain as it has been shown that deficiency of proopiomelanocortin (POMC) [10,11] and melanocortin 4 receptors (MC4R) [12–15] in both rodents and humans results in severe hyperphagia and obesity [16–23] . In this review, we will summarize how the central melanocortin pathway helps regulate body mass and adiposity within a ‘healthy’ range through the ‘nutrient sensing’ network [24–28] . This article is part of a Special Issue entitled: Melanocortin Receptors - edited by Ya-Xiong Tao. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09254439
Volume :
1863
Issue :
10A
Database :
Academic Search Index
Journal :
BBA: Molecular Basis of Disease
Publication Type :
Academic Journal
Accession number :
125100088
Full Text :
https://doi.org/10.1016/j.bbadis.2017.05.007