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Progesterone-Induced miR-152 Inhibits the Proliferation of Endometrial Epithelial Cells by Downregulating WNT-1.
- Source :
-
Reproductive Sciences . Oct2017, Vol. 24 Issue 10, p1444-1453. 10p. - Publication Year :
- 2017
-
Abstract
- Progesterone (P4) is an important ovarian hormone that inhibits estrogen-dependent proliferation of endometrial epithelial cells (EECs). miR-152 has been reported to be a cell cycle regulator. In this study, we first demonstrated that P4 induced the expression of miR-152 in ovariectomized mice and Ishikawa cell. miR-152 was detected in the human endometrial cell lines that were stably transfected with P4 receptor. Results showed that P4 induced its expression through its receptor B subtype. Then, using the specific miRNA mimic and inhibitor, we proved that miR-152 impeded G1/S transition in the cell cycle of EECs and inhibited cellular proliferation via downregulating WNT-1 in mice and human endometrial cancer cell lines (Ishikawa, HEC-1-b, and KLE). miR-152 induced by P4 is an important inhibitor for the proliferation of EECs. miR-152 may be an important tumor suppressor microRNA in endometrial cancer. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 19337191
- Volume :
- 24
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- Reproductive Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 125143579
- Full Text :
- https://doi.org/10.1177/1933719116689595