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Bioactive ent-kaurane diterpenoids from Isodon rubescens.
- Source :
-
Phytochemistry . Nov2017, Vol. 143, p199-207. 9p. - Publication Year :
- 2017
-
Abstract
- Seven previously undescribed 7,20-epoxy- ent -kaurane diterpenoids, isojiangrubesins A–G, along with seventeen known ones, were isolated from the aerial parts of Isodon rubescens . Their structures were characterized on the basis of spectroscopic methods and signal-crystal X-ray diffraction. All of these compounds were evaluated for their in vitro cytotoxicity against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW480). Four isolates exhibited significant inhibitory ability against all cell lines, with IC 50 values ranging from 0.5 to 6.5 μ M; They also strongly inhibited NO production in LPS-stimulated RAW264.7 cells. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00319422
- Volume :
- 143
- Database :
- Academic Search Index
- Journal :
- Phytochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 125178156
- Full Text :
- https://doi.org/10.1016/j.phytochem.2017.08.009