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Enhanced Stabilization in Dried Silk Fibroin Matrices.
- Source :
-
Biomacromolecules . Sep2017, Vol. 18 Issue 9, p2900-2905. 6p. - Publication Year :
- 2017
-
Abstract
- Preliminary studies have shown that silk fibroin can protect biomacromolecules from thermal degradation, but a deeper understanding of underlying mechanisms needed to fully leverage the stabilizing potential of this matrix has not been realized. In this study, we investigate stabilization of plasma C-reactive protein (CRP), a diagnostic indicator of infection or inflammation, to gain insight into stabilizing mechanisms of silk. We observed that the addition of antiplasticizing excipients that suppress β-relaxation amplitudes in silk matrices resulted in enhanced stability of plasma CRP. These observations are consistent with those made in sugar-glass-based protein-stabilizing matrices and suggest fundamental insight into mechanisms as well as practical strategies to employ with silk protein matrices for enhanced stabilization utility. [ABSTRACT FROM AUTHOR]
- Subjects :
- *SILK fibroin
*BIOMACROMOLECULES
*BLOOD proteins
*INFLAMMATION
*EXCIPIENTS
Subjects
Details
- Language :
- English
- ISSN :
- 15257797
- Volume :
- 18
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Biomacromolecules
- Publication Type :
- Academic Journal
- Accession number :
- 125211321
- Full Text :
- https://doi.org/10.1021/acs.biomac.7b00857