微型游离腓动脉穿支皮瓣修复术治疗手部小创面感染的效果及对血清炎性因子的影响

Objective: To study the clinical effect of free peroneal artery perforator flap on the small wound of hand infection and its effects on the serum inflammatory factors. Methods: 90 patients with small wound of hand who were treated in our hospital from October 2014 to October 2016 were selected and divided into the observation group (n=45) and the control group (n=45). according to the random number table. The control group was treated with inferior epigastric artery perforator flap repair, while the observation group was treated with free peroneal artery perforator flap. Then the operative effect and serum interleukin (IL)-6, IL -8, interferon (INF)-7, tumor necrosis factor (TNF)-α, procalcitonin(PCR), high sensitive C reactive protein(hs-CRP) levels before and after treatment as well as the incidence of infection were compared between two groups. Results: Compared with those before operation, the levels of serum IL-6, IL-8, INF-γ，TNF-α, procalcitonin(PCR), high sensitive C reactive protein(hs-CRP), erythrocyte sedimentation rate (ESR) of both groups were significantly decreased, which were obviously lower in the observation group than those of the control group(P< 0.05); the excellent and good rate after operation in the observation group was higher than that of the control group (P< 0.05); the infection rate of the observation group was lower than that of the control group (P< 0.05). Conclusion: Free peroneal artery perforator flap was effective and safe for small wound of hand, which could significantly inhibit the inflammatory response and desease the postoperative infection. [ABSTRACT FROM AUTHOR]