Back to Search
Start Over
A sweet development in Notch regulation.
- Source :
-
Journal of Biological Chemistry . 9/22/2017, Vol. 292 Issue 38, p15974-15975. 2p. - Publication Year :
- 2017
-
Abstract
- The transmembrane signaling protein Notch, which is crucial for embryonic cell fate decisions, has 36 extracellular EGF domains that are glycosylated in variable and complex ways. A new study shows that O-fucose and O-glucose stabilize the repeats but that extension of glucose by xylose weakens stability, explained by the binding of the glycan to a protein groove. This work shows how different types of glycosylation can distinctly influence protein stability and structure. [ABSTRACT FROM AUTHOR]
- Subjects :
- *NOTCH signaling pathway
*NOTCH proteins
*GLUCOSE
*GLYCANS
*GLYCOSYLATION
Subjects
Details
- Language :
- English
- ISSN :
- 00219258
- Volume :
- 292
- Issue :
- 38
- Database :
- Academic Search Index
- Journal :
- Journal of Biological Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 125334625
- Full Text :
- https://doi.org/10.1074/jbc.H117.800102