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Euphorbia kansui Attenuates Insulin Resistance in Obese Human Subjects and High-Fat Diet-Induced Obese Mice.
- Source :
-
Evidence-based Complementary & Alternative Medicine (eCAM) . 10/4/2017, Vol. 2017, p1-9. 9p. 1 Diagram, 1 Chart, 2 Graphs. - Publication Year :
- 2017
-
Abstract
- Background. Obesity is a main cause of insulin resistance (IR), metabolic syndrome, and fatty liver diseases. This study evaluated Euphorbia kansui radix (Euphorbia) as a potential treatment option for obesity and obesity-induced IR in obese human and high-fat diet- (HFD-) induced obese mice. Methods. In the human study, we analyzed the body weight change of 14 patients who took a single dose of 6 g of Euphorbia powder. In the animal study, male mice were divided into three groups: normal chow, HFD, and Euphorbia (high-fat diet and 100 mg/Kg Euphorbia once per week). Body weight, epididymal fat pad weight, fasting blood glucose, fasting insulin, HOMA-IR, and oral glucose tolerance test were measured. Also, macrophage infiltration and expression of CD68, tumor necrosis factor- (TNF-) α, interferon- (IFN-) γ, and interleukin- (IL-) 6 genes in the liver and adipose tissue were analyzed. Results. The human study showed that Euphorbia has a potential effect on body weight loss. In the in vivo study, body weight, epididymal fat weight, glucose level, IR, expression of CD68, TNF-α, IFN-r, and IL-6 genes, and macrophages in liver and adipose tissue were significantly reduced by Euphorbia. Conclusions. These results suggest that Euphorbia attenuates obesity and insulin resistance via anti-inflammatory effects. [ABSTRACT FROM AUTHOR]
- Subjects :
- *OBESITY complications
*ADIPOSE tissues
*ANIMAL experimentation
*BLOOD sugar
*BODY weight
*FATTY liver
*GENES
*GLUCOSE tolerance tests
*INFLAMMATION
*INSULIN
*INSULIN resistance
*INTERFERONS
*INTERLEUKINS
*LIVER
*MACROPHAGES
*MEDICINAL plants
*MICE
*OBESITY
*PROTEINS
*TUMOR necrosis factors
*WEIGHT loss
*PLANT extracts
*METABOLIC syndrome
*IN vivo studies
Subjects
Details
- Language :
- English
- ISSN :
- 1741427X
- Volume :
- 2017
- Database :
- Academic Search Index
- Journal :
- Evidence-based Complementary & Alternative Medicine (eCAM)
- Publication Type :
- Academic Journal
- Accession number :
- 125482725
- Full Text :
- https://doi.org/10.1155/2017/9058956