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Novel Biodegradable Polymer with Redox-Triggered Backbone Cleavage Through Sequential 1,6-Elimination and 1,5-Cyclization Reactions.
- Source :
-
Macromolecular Rapid Communications . Oct2017, Vol. 38 Issue 19, pn/a-N.PAG. 6p. - Publication Year :
- 2017
-
Abstract
- In the past decade, the self-immolative biodegradable polymer arose as a novel paradigm for its efficient degradation mechanism and vast potential for advanced biomedical applications. This study reports successful synthesis of a novel biodegradable polymer capable of self-immolative backbone cleavage. The monomer is designed by covalent conjugations of both pendant redox-trigger (p-nitrobenzyl alcohol) and self-immolative linker (p-hydroxybenzyl alcohol) to the cyclization spacer (n-2-(hydroxyethyl)ethylene diamine), which serves as the structural backbone. The polymerization of the monomer with hexamethylene diisocyanate yields a linear redox-sensitive polymer that can systemically degrade via sequential 1,6-elimination and 1,5-cyclization reactions within an effective timeframe. Ultimately, the polymer's potential for biomedical application is simulated through in vitro redox-triggered release of paclitaxel from polymeric nanoparticles. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10221336
- Volume :
- 38
- Issue :
- 19
- Database :
- Academic Search Index
- Journal :
- Macromolecular Rapid Communications
- Publication Type :
- Academic Journal
- Accession number :
- 125483038
- Full Text :
- https://doi.org/10.1002/marc.201700395