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Chase-and-run dynamics in cell motility and the molecular rupture of interacting active elastic dimers.
- Source :
-
Physical Review E . Sep2017, Vol. 96 Issue 3, p1-1. 1p. - Publication Year :
- 2017
-
Abstract
- Cell migration in morphogenesis and cancer metastasis typically involves interplay between different cell types. We construct and study a minimal, one-dimensional model composed of two different motile cells with each cell represented as an active elastic dimer. The interaction between the two cells via cadherins is modeled as a spring that can rupture beyond a threshold force as it undergoes dynamic loading from the interacting motile cells. We obtain a phase diagram consisting of chase-and-run dynamics and clumping dynamics as a function of the stiffness of the interaction spring and the threshold force and, therefore, posit that active rupture, or rupture via active forces, is a mechanosensitive means to regulate dynamics between cells. Since the parameters in the model differentiate between N- and E-cadherins, we make predictions for the interactions between a placodelike cell and a neural crestlike cell in a microchannel as well as discuss how our results inform chase-and-run dynamics found in a group of placode cells interacting with a group of neural crest cells. In particular, an argument was made in the latter case that the feedback between cadherins and cell-substrate interaction via integrins was necessary to obtain the chase-and-run behavior. Based on our two-cell results, we argue that this feedback accentuates, but is not necessary for, the chase-and-run behavior. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CELL motility
*ELASTICITY
*METASTASIS
Subjects
Details
- Language :
- English
- ISSN :
- 24700045
- Volume :
- 96
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Physical Review E
- Publication Type :
- Academic Journal
- Accession number :
- 125618356
- Full Text :
- https://doi.org/10.1103/PhysRevE.96.032407