Back to Search Start Over

Lack of association between SLC5A7 polymorphisms and Tourette syndrome in a Chinese Han population.

Lack of association between SLC5A7 polymorphisms and Tourette syndrome in a Chinese Han population.

Authors :
Liu, Wenmiao
Qiu, Shiyan
Gao, Chuanping
Wang, Guiju
Liu, Shiguo
Guan, Hongzai
Source :
Neuroscience Letters. Sep2017, Vol. 658, p161-164. 4p.
Publication Year :
2017

Abstract

Although Tourette syndrome (TS) is a chronic neuropsychiatric disorder whose pathogenesis remains unclear, genetic factors play an important role in the occurrence and development. A variety of studies have been shown that the candidate genes related to cholinergic neurons may be associated with the onset of TS. To investigate the association between the SLC5A7 polymorphisms and Tourette syndrome (TS) in the Chinese Han population, the SNP rs1013940, rs2433718, and rs4676169 were genotyped in 401 TS trios and 400 controls. The transmission disequilibrium test (TDT) and haplotype relative risk (HRR) compared genetic distributions of trios, while the chi-square test compared patients and controls. However, no transmission disequilibrium was found between the three SLC5A7 SNPs and TS. Therefore, we think that this gene may not be the main risk factor on the onset of TS. However, these results should be further validated in different populations. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
03043940
Volume :
658
Database :
Academic Search Index
Journal :
Neuroscience Letters
Publication Type :
Academic Journal
Accession number :
125704384
Full Text :
https://doi.org/10.1016/j.neulet.2017.08.041