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Developing PreDICT – a fully integrated data platform for preclinical in vivo data: learning from experience.
- Source :
-
Drug Discovery Today . Oct2017, Vol. 22 Issue 10, p1539-1546. 8p. - Publication Year :
- 2017
-
Abstract
- In vivo models have been crucial for developing our understanding of key processes associated with human disease and developing novel therapeutics. These in vivo studies are becoming increasingly complex, requiring long-term efficacy data and additional supportive datasets such as pharmacokinetic profiles and analysis of multiple biomarkers of pharmacodynamic response and efficacy. Moreover, a new agent will be investigated in many different models and often in combination with other drugs. Despite advances across the industry integrating and analysing complex datasets, management of in vivo data remains an ongoing challenge across the industry. Here, we describe a project that has successfully delivered a working solution to integrate pharmacokinetic, biomarker and efficacy data, independent of therapy area. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13596446
- Volume :
- 22
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- Drug Discovery Today
- Publication Type :
- Academic Journal
- Accession number :
- 125723629
- Full Text :
- https://doi.org/10.1016/j.drudis.2017.07.014