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Fetal Cardiac Impairment in Nitrofen-Induced Congenital Diaphragmatic Hernia: Postmortem Microcomputed Tomography Imaging Study.
- Source :
-
Fetal & Pediatric Pathology . Aug2017, Vol. 36 Issue 4, p282-293. 12p. - Publication Year :
- 2017
-
Abstract
- Introduction: We assessed the post-mortem micro-CT utility to evaluate fetal cardiac impairment in nitrofen-induced congenital diaphragmatic hernia (CDH).Methods: At 9.5d postconception (dpc), pregnant rats were exposed to nitrofen. At +18 and +21dpc, fetuses were harvested by cesarean section. Postmortem micro-CT and autopsy were performed. Fetuses were assigned to three experimental groups: Control group (C), Nitrofen group (N, exposition to nitrofen without CDH), CDH group. Cardio-pulmonary indices were evaluated.Results: An accurate morphological evaluation of the lung and heart was obtained. Early cardiac impairment was present in the N and CDH groups. At term pregnancy, an increased maximum diameter and decreased minimum diameter of the ventricles and increased interventricular septal thickness were noted in CDH. Histology showed a myocardial “disarray” and an high density of mitotic myocytes in CDH at midgestation.Conclusions: The potential utility of post-mortem fetal micro-CT examination in CDH was introduced. The results highlighted the presence of cardiac adaptation in affected fetuses. [ABSTRACT FROM PUBLISHER]
Details
- Language :
- English
- ISSN :
- 15513815
- Volume :
- 36
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Fetal & Pediatric Pathology
- Publication Type :
- Academic Journal
- Accession number :
- 125723878
- Full Text :
- https://doi.org/10.1080/15513815.2017.1315198