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Pyrrolizidine alkaloid-derived DNA adducts are common toxicological biomarkers of pyrrolizidine alkaloid N-oxides.
- Source :
-
Journal of Food & Drug Analysis . Oct2017, Vol. 25 Issue 4, p984-991. 8p. - Publication Year :
- 2017
-
Abstract
- There are 660 pyrrolizidine alkaloids (PAs) and PA N-oxides present in the plants, with approximately half being possible carcinogens. We previously reported that a set of four PA-derived DNA adducts is formed in the liver of rats administered a series of hepatocarcinogenic PAs and a PA N-oxide. Based on our findings, we hypothesized that this set of DNA adducts is a common biological biomarker of PA-induced liver tumor formation. In this study, we determined that rat liver microsomal metabolism of five hepatocarcinogenic PAs (lasiocarpine, retrorsine, riddelliine, monocrotaline, and heliotrine) and their corresponding PA N-oxides produced the same set of DNA adducts. Among these compounds, lasiocarpine N-oxide, retrorsine N-oxide, monocrotaline N-oxide, and heliotrine N-oxide are for first time shown to be able to produce these DNA adducts. These results further support the role of these DNA adducts as potential common biomarkers of PA-induced liver tumor initiation. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10219498
- Volume :
- 25
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Journal of Food & Drug Analysis
- Publication Type :
- Academic Journal
- Accession number :
- 125725594
- Full Text :
- https://doi.org/10.1016/j.jfda.2017.09.001