Back to Search
Start Over
Black Pigment Gallstone Inspired Platinum-Chelated Bilirubin Nanoparticles for Combined Photoacoustic Imaging and Photothermal Therapy of Cancers.
- Source :
-
Angewandte Chemie International Edition . 10/23/2017, Vol. 56 Issue 44, p13684-13688. 5p. - Publication Year :
- 2017
-
Abstract
- Bilirubin (BR), a bile pigment that exerts potent antioxidant and anti-inflammatory effects, is also a major constituent of black pigment gallstones found in bile ducts under certain pathological conditions. Inspired by the intrinsic metal-chelating power of BR found in gallstones, herein we report a cisplatin-chelated BR-based nanoparticle (cisPt@BRNP) for use as a new photonic nanomedicine for combined photoacoustic imaging and photothermal therapy of cancers. The cisPt@BRNPs were prepared by simply mixing cisplatin with BRNPs, yielding ca. 150-nm-size NPs. Upon near-IR laser irradiation at 808 nm, cisPt@BRNPs generated considerable heat and induced clear death of cancer cells in vitro. Following intravenous injection into human colon cancer-bearing mice, cisPt@BRNPs allowed effective tumor visualization by photoacoustic imaging and remarkable antitumor efficacy by photothermal therapy, suggesting their potential for use as a new photonic nanomedicine for cancer therapy. [ABSTRACT FROM AUTHOR]
- Subjects :
- *GALLSTONES
*BILIRUBIN
*ACOUSTIC imaging
*CANCER treatment
*NANOMEDICINE
Subjects
Details
- Language :
- English
- ISSN :
- 14337851
- Volume :
- 56
- Issue :
- 44
- Database :
- Academic Search Index
- Journal :
- Angewandte Chemie International Edition
- Publication Type :
- Academic Journal
- Accession number :
- 125743704
- Full Text :
- https://doi.org/10.1002/anie.201707137