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Stimuli-Responsive Dipeptide-Protein Hydrogels through Schiff Base Coassembly.
- Source :
-
Macromolecular Rapid Communications . Oct2017, Vol. 38 Issue 20, pn/a-N.PAG. 7p. - Publication Year :
- 2017
-
Abstract
- Different from the conventional irreversible covalent conjugations, a simple and efficient dynamic Schiff base covalent assembly is developed to construct the stable and smart dipeptide-protein hydrogels under mild conditions. Diphenylalanine-hemoglobin hydrogel is chosen to investigate the gelation formation process and mechanism. It is found that such assembled dipeptide-protein hydrogels are sensitive to pH variation, and simultaneously the proteins can be released without changing the native secondary structures from the gels. Furthermore, these adaptive hydrogels can encapsulate a series of small molecules, multicomponent proteins, and functional nanoparticles. These versatile hydrogels may find a great potential in bioapplications. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HYDROGELS
*SCHIFF bases
*DIPEPTIDES
*PROTEINS
*GELATION
Subjects
Details
- Language :
- English
- ISSN :
- 10221336
- Volume :
- 38
- Issue :
- 20
- Database :
- Academic Search Index
- Journal :
- Macromolecular Rapid Communications
- Publication Type :
- Academic Journal
- Accession number :
- 125744289
- Full Text :
- https://doi.org/10.1002/marc.201700408