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Sequence determination of the Crimean–Congo hemorrhagic fever virus L segment
- Source :
-
Virology . Mar2004, Vol. 321 Issue 1, p23. 6p. - Publication Year :
- 2004
-
Abstract
- Crimean–Congo hemorrhagic fever (CCHF) virus is highly pathogenic for humans and remains the only Category A virus for which full sequence information is currently unavailable. In this study we completed CCHF genome characterization by determining the L segment sequence using Dugbe and CCHF virus-specific oligonucleotides. Sequence alignments revealed the presence of four previously described conserved regions in all Bunyaviridae polymerases. Interestingly, additional regions containing putative Ovarian Tumor (OTU)-like cysteine protease and helicase domains were identified in the L segments of CCHF and Dugbe viruses, suggesting an autoproteolytic cleavage process for nairovirus L proteins. [Copyright &y& Elsevier]
- Subjects :
- *BUNYAVIRUSES
*HEMORRHAGIC fever
*INFLUENZA
*RIFT Valley fever
Subjects
Details
- Language :
- English
- ISSN :
- 00426822
- Volume :
- 321
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Virology
- Publication Type :
- Academic Journal
- Accession number :
- 12578217
- Full Text :
- https://doi.org/10.1016/j.virol.2003.09.046