Synthesis, Structural, and Antitumor Studies of Some 5-Fluorocytosine and Guanine Complexes.

Mixed-ligand complexes of Co(II), Ni(II), Cu(II), Zn(II), and Cd(II) with 5-fluorocytosine (5FC) and guanine (G) have been prepared in aqueous ethanol solution at pH of about 7. The prepared complexes were characterized by various physico-chemical methods viz. elemental analyses, infrared, UV-visible, magnetic measurements, and powder x-ray pattern. On the basis of IR studies, it is suggested that G acts as bidentate ligand coordinating through the N3 and N7 nitrogens whereas 5FC behaves as a monodentate and coordinates to the metal ions through the carbonyl oxygen only. These complexes were subjected to a screening system of Dalton's lymphoma (DL) tumor cells both in vivo and in vitro. Some complexes exhibit significant antitumor activity both in vivo and in vitro. [ABSTRACT FROM AUTHOR]