Natural polyreactive IgA antibodies coat the intestinal microbiota.

Authors :: Bunker, Jeffrey J.
Erickson, Steven A.
Flynn, Theodore M.
Henry, Carole
Koval, Jason C.
Meisel, Marlies
Jabri, Bana
Antonopoulos, Dionysios A.
Wilson, Patrick C.
Bendelac, Albert
Source :: Science. 10/20/2017, Vol. 358 Issue 6361, p320-320. 1p. 1 Diagram.
Publication Year :: 2017
Abstract: The article analyzes the role of immunoglobulin A (IgA), the most abundant mammalian antibody isotype, in containing the resident commensal microbiota in the intestines. IgA is particularly prevalent at barrier surfaces and offers protection against enteric pathogens. Cloning of monoclonal antibodies (mAbs) from single murine IgA plasma cells is done to study the specificity of homeostatic IgA.