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Neuroendocrine disruption without direct endocrine mode of action: Polychloro-biphenyls (PCBs) and bisphenol A (BPA) as case studies.
- Source :
-
Comptes Rendus Biologies . Sep2017, Vol. 340 Issue 9/10, p432-438. 7p. - Publication Year :
- 2017
-
Abstract
- Endocrine disruption is commonly thought to be restricted to a direct endocrine mode of action i.e. the perturbation of the activation of a given type of hormonal receptor by its natural ligand. Consistent with the WHO definition of an endocrine disrupter, a key issue is the “altered function(s) of the endocrine system”. Such altered functions can result from different chemical interactions, beyond agonistic or antagonistic effect at a given receptor. Based on neuroendocrine disruption by polychlorinated biphenyls and bisphenol A, this paper proposes different mechanistic paradigms that can result in adverse health effects. They are a consequence of altered endocrine function(s) secondary to chemical interaction with different steps in the physiological regulatory processes, thus accounting for a possibly indirect endocrine mode of action. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 16310691
- Volume :
- 340
- Issue :
- 9/10
- Database :
- Academic Search Index
- Journal :
- Comptes Rendus Biologies
- Publication Type :
- Academic Journal
- Accession number :
- 125923757
- Full Text :
- https://doi.org/10.1016/j.crvi.2017.07.006