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Hepatocyte growth factor (HGF) optimizes oral traumatic ulcer healing of mice by reducing inflammation.
- Source :
-
Cytokine . Nov2017, Vol. 99, p275-280. 6p. - Publication Year :
- 2017
-
Abstract
- Objective To evaluate the influence of overexpression HGF on the healing of traumatic ulcer of oral mucosa of mice. Material and methods Mice were divided into two groups: wild type C57BL6(WT) and HGF high expression transgenic (HGF-Tg) mice. Traumatic ulcer of all mice were made by number 15 scalpel blade. Mice were sacrificed after 5 days and the inflammation score and expression of TNFα, IFNγ, c-Met, apoptosis (TUNEL) and 40 serum inflammation cytokines were estimated. Results HGF-Tg mice presented a lower inflammation score (p = 0.011), Serum TNFα expression in HGF-Tg ulcers is 1.3 times than WT ulcer and the difference is statistical significance ( t test, p = 0.003). Serum c-Met protein in HGF-Tg mice were significantly higher than WT mice ( t test, p = 0.004). No statistical difference was observed in the serum IFNγ between WT ulcer and HGF-Tg ulcer ( t test, p = 0.268). TNFα positive cytoplasm expression cells in connective tissue of HGF-Tg mice is significantly lower than that of WT group ( t test, p = 0.029). C-Met positive cytoplasm expression cells in both epithelium and connective tissue of HGF-Tg group is significantly higher than that of WT group ( t test, p = 0.040, p = 0.000). Samples in HGF-Tg group showed a lower number of positive cells of epithelium TUNEL staining compared with that in the WT group ( t test, p = 0.035). Conclusions HGF exhibited anti-inflammatory potential in oral traumatic ulcer through the reduction of epithelial apoptosis, connective tissue TNFα expression and induction of c-Met expression. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10434666
- Volume :
- 99
- Database :
- Academic Search Index
- Journal :
- Cytokine
- Publication Type :
- Academic Journal
- Accession number :
- 125945855
- Full Text :
- https://doi.org/10.1016/j.cyto.2017.08.006