Can effective containment of wild polioviruses in laboratories and inactivated poliovirus vaccine production sites ever be achieved?

Examines the viability of containing wild polioviruses in laboratories and inactivated poliovirus vaccine production sites. Mutations of vaccine virus during the initial passages through the human intestine; Chances of accidental release of wild poliovirus; Transmission of wild poliovirus from the laboratory to the community; Challenge of testing a collection of enteroviruses for the presence of wild poliovirus.