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Lysophosphatidylserine suppresses IL-2 production in CD4 T cells through LPS3/GPR174.
- Source :
-
Biochemical & Biophysical Research Communications . Dec2017, Vol. 494 Issue 1/2, p332-338. 7p. - Publication Year :
- 2017
-
Abstract
- Lysophosphatidylserine (LysoPS) has been shown to have lipid mediator-like actions to induce mast cell degranulation and suppress T lymphocyte proliferation. Recently, three G protein-coupled receptors (GPCRs), LPS 1 /GPR34, LPS 2 /P2Y10, and LPS 3 /GPR174, were found to react specifically with LysoPS, raising the possibility that LysoPS exerts its roles through these receptors. In this study, we show that LPS 3 is expressed in various T cell subtypes and is involved in suppression of Interleukin-2 (IL-2) production in CD4 T cells. We found that LysoPS suppressed the IL-2 production from activated T cells at the mRNA and protein levels. In addition, LysoPS did not have such an effect on the splenocytes and CD4 T cells isolated from LPS 3 -deficient mice. In LPS 3 -deficient splenocytes and CD4 T cells, anti-CD3/anti-CD28-triggered IL-2 production is somewhat increased. Interestingly, LysoPS with various fatty acids was up-regulated upon T cell activation. The present study raised the possibility that LysoPS exerts its immunosuppressive roles by down-regulating IL-2 production through a LysoPS-LPS 3 axis in T cells. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0006291X
- Volume :
- 494
- Issue :
- 1/2
- Database :
- Academic Search Index
- Journal :
- Biochemical & Biophysical Research Communications
- Publication Type :
- Academic Journal
- Accession number :
- 125968579
- Full Text :
- https://doi.org/10.1016/j.bbrc.2017.10.028