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SNP-Based Heritability Estimates of Common and Specific Variance in Self- and Informant-Reported Neuroticism Scales.
- Source :
-
Journal of Personality . Dec2017, Vol. 85 Issue 6, p906-919. 14p. 3 Charts, 1 Graph. - Publication Year :
- 2017
-
Abstract
- <bold>Objective: </bold>Our study aims to estimate the proportion of the phenotypic variance of Neuroticism and its facet scales that can be attributed to common single-nucleotide polymorphisms (SNPs) in two adult populations from Estonia (EGCUT; N = 3,292) and the Netherlands (Lifelines; N = 13,383).<bold>Method: </bold>Genomic-relatedness-matrix restricted maximum likelihood (GREML) using genome-wide complex trait analysis (GCTA) software was employed. To build upon previous research, we used self- and informant reports of the 30-facet NEO personality inventories and analyzed both the usual sum scores and the residual facet scores of Neuroticism.<bold>Results: </bold>In the EGCUT cohort, the proportion of phenotypic variance explained by the additive effects of common genetic variants in self- and informant-reported Neuroticism domain scores was 15.2% (p = .070, SE = .11) and 6.2% (p = .293, SE = .12), respectively. The SNP-based heritability estimates at the level of Neuroticism facet scales differed greatly across cohorts and modes of measurement but were generally higher (a) for self- than for informant reports, and (b) for sum than for residual scores.<bold>Conclusions: </bold>Our findings indicate that a large proportion of the heritability of Neuroticism is not captured by additive genetic effects of common SNPs, with some evidence for Gene × Environment interaction across cohorts. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00223506
- Volume :
- 85
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Journal of Personality
- Publication Type :
- Academic Journal
- Accession number :
- 126172458
- Full Text :
- https://doi.org/10.1111/jopy.12297