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Long-term impairment attributable to congenital cytomegalovirus infection: a retrospective cohort study.
- Source :
-
Developmental Medicine & Child Neurology . Dec2017, Vol. 59 Issue 12, p1261-1268. 8p. - Publication Year :
- 2017
-
Abstract
- <bold>Aim: </bold>This study aimed to estimate long-term impairment attributable to congenital cytomegalovirus infection (cCMV).<bold>Method: </bold>This nationwide cohort study retrospectively assessed cCMV in children born in 2008 in the Netherlands, testing 31 484 stored neonatal dried blood spots. Extensive medical data of cCMV-positive children (n=133) and matched cCMV-negative comparison children (n=274) up to 6 years of age were analysed.<bold>Results: </bold>Moderate to severe long-term impairment was diagnosed in 24.8% (33 out of 133) of all cCMV-positive children (53.8% in symptomatic, 17.8% in asymptomatic), compared with 12.0% (33 out of 274) of cCMV-negative children. Sensorineural hearing loss was seen only in five cCMV-positive children (3.8%). Developmental delays were diagnosed more often in cCMV-positive children than cCMV-negative children: motor (12.0% vs 1.5%), cognitive (6.0% vs 1.1%), and speech-language (16.5% vs 7.3%). Long-term impairment in multiple domains was more frequent in symptomatic (19.2%) and asymptomatic (8.4%) cCMV-positive children than cCMV-negative children (1.8%).<bold>Interpretation: </bold>Children with cCMV were twice as likely to have long-term impairment up to the age of 6 years, especially developmental delays and sensorineural hearing loss, than cCMV-negative comparison children, with a risk difference of 12.8%. These insights into the risk of cCMV-associated impairment can help optimize care and stimulate preventive measures.<bold>What This Paper Adds: </bold>Congenital cytomegalovirus infection (cCMV) leads to impairment in 25% of cases. Fifty per cent of children with cCMV symptoms at birth have long-term impairment. The risk difference of moderate to severe long-term impairment between children with and without cCMV is 13%, attributable to cCMV. cCMV leads to motor, cognitive, and speech-language developmental delay in children. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CYTOMEGALOVIRUS diseases
*CYTOMEGALOVIRUSES
*DEVELOPMENTAL neurobiology
*AUDITORY perception in children
*NEURAL development
*CEREBRAL cortex development
*DEAFNESS
*DEVELOPMENTAL disabilities
*LANGUAGE disorders
*PEOPLE with intellectual disabilities
*RETROSPECTIVE studies
*DYADIC Adjustment Scale
*DISEASE complications
Subjects
Details
- Language :
- English
- ISSN :
- 00121622
- Volume :
- 59
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Developmental Medicine & Child Neurology
- Publication Type :
- Academic Journal
- Accession number :
- 126217311
- Full Text :
- https://doi.org/10.1111/dmcn.13556