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BDE-47 and BDE-85 stimulate insulin secretion in INS-1 832/13 pancreatic β-cells through the thyroid receptor and Akt.
- Source :
-
Environmental Toxicology & Pharmacology . Dec2017, Vol. 56, p29-34. 6p. - Publication Year :
- 2017
-
Abstract
- PBDEs (polybrominated diphenyl ethers) are environmental pollutants that have been linked to the development of type 2 diabetes, however, the precise mechanisms are not clear. Particularly, their direct effect on insulin secretion is unknown. In this study, we show that two PBDE congeners, BDE-47 and BDE-85, potentiate glucose-stimulated insulin secretion (GSIS) in INS-1 832/13 cells. This effect of BDE-47 and BDE-85 on GSIS was dependent on thyroid receptor (TR). Both BDE-47 and BDE-85 (10 μM) activated Akt during an acute exposure. The activation of Akt by BDE-47 and BDE-85 plays a role in their potentiation of GSIS, as pharmacological inhibition of PI3K, an upstream activator of Akt, significantly lowers GSIS compared to compounds alone. This study shows that BDE-47 and BDE-85 directly act on pancreatic β-cells to stimulate GSIS, and that this effect is mediated by the thyroid receptor (TR) and Akt activation. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13826689
- Volume :
- 56
- Database :
- Academic Search Index
- Journal :
- Environmental Toxicology & Pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 126294207
- Full Text :
- https://doi.org/10.1016/j.etap.2017.08.030