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Photo-induced synthesis and in vitro antitumor activity of Fenestin A analogs.
- Source :
-
New Journal of Chemistry . 12/7/2017, Vol. 41 Issue 23, p14044-14048. 5p. - Publication Year :
- 2017
-
Abstract
- Two novel Fenestin A analogs (1 and 2) containing a phthalimide moiety are prepared by photoinduced cyclization. Their absolute configurations were determined by experimental ECD with the aid of theoretical calculations. The resulting compounds are active in HeLa (IC50 = 28.2 μM for 1 and 36.5 μM for 2) and HepG-2 cell lines (IC50 = 33.5 μM for 1 and 40.3 μM for 2). [ABSTRACT FROM AUTHOR]
- Subjects :
- *INSULIN derivatives
*CHEMICAL synthesis
*ANTINEOPLASTIC agents
Subjects
Details
- Language :
- English
- ISSN :
- 11440546
- Volume :
- 41
- Issue :
- 23
- Database :
- Academic Search Index
- Journal :
- New Journal of Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 126326157
- Full Text :
- https://doi.org/10.1039/c7nj03363j