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Generation of ϵ,ϵ-Difluorinated Metal-Pentadienyl Species through Lanthanide-Mediated C−F Activation.
- Source :
-
Chemistry - A European Journal . 11/21/2017, Vol. 23 Issue 65, p16460-16465. 6p. - Publication Year :
- 2017
-
Abstract
- Heavy metal on Lewis acid: The combination of lanthanide metals and AlCl3 has been employed for selective single C−F activation in benzofulvenes comprising an exocyclic CF3 substituent. Intermediate ϵ,ϵ-difluorinated metal-dienyl species react with a large variety of aldehydes in a highly regio- and diastereoselective fashion to afford 1,1-disubstituted indenes bearing a difluorovinyl group. These new building blocks have been further transformed through a hydrogenation-cyclization process into fluorinated heterocyclic spiro compounds. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09476539
- Volume :
- 23
- Issue :
- 65
- Database :
- Academic Search Index
- Journal :
- Chemistry - A European Journal
- Publication Type :
- Academic Journal
- Accession number :
- 126335649
- Full Text :
- https://doi.org/10.1002/chem.201704322