丁丙诺啡透皮贴剂对慢性膝骨性关节炎疼痛的控制效果评价.

Objective: To evaluate the clinical efficacy and safety of using buprenorphine transdermal patch in the treatment of patients with knee osteoarthritis. Methods: 112 cases of knee osteoarthritis were divided into 2 groups: the experimental group (n=56) was treated with a total of two patches of buprenorphine (5 mg) transdermal patch on the outside of upper arm, and each patch had been kept for 7 days. The control group (n=56) was given 20 mg celecoxib orally twice daily for two weeks. patients were standardized using analgesics according to the VAS score. McMaster Universities Osteoarthritis Index (WOMAC), and adverse reactions. Results: 112 cases of knee osteoarthritis patients were observed. The visual analog scale (VAS) reported by patients in the experimental group and the control group were significantly decreased after two weeks treatment (P<0.05). However, there was no significant difference between 2 groups. The WOMAC score in the experiment group and the control group were significantly decreased after the treatment (P<0.05). There was no significant difference between the two groups (P>0.05). There was no significant difference between 2 groups in complication and adverse reactions. Conclusions: Buprenorphine transdermal patches is at least as effective as celecoxib in treating knee osteoarthritis which could be further used in clinic therapy because of its easy using. [ABSTRACT FROM AUTHOR]