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Pharmacotherapy for Irritable Bowel Syndrome.
- Source :
-
Journal of Clinical Medicine . Nov2017, Vol. 6 Issue 11, p101. 16p. - Publication Year :
- 2017
-
Abstract
- Irritable bowel syndrome (IBS) is a disorder of the brain-gut axis; the pathophysiological mechanisms include altered colonic motility, bile acid metabolism, neurohormonal regulation, immune dysfunction, alterations in the epithelial barrier and secretory properties of the gut. This article reviews the mechanisms, efficacy, and safety of current pharmacotherapy, and medications that are in phase III trials for the treatment of IBS. There remains a significant unmet need for effective treatments—particularly for the pain component of IBS—although the introduction of drugs directed at secretion, motility and a non-absorbable antibiotic provide options for the bowel dysfunction in IBS. [ABSTRACT FROM AUTHOR]
- Subjects :
- *IRRITABLE colon
*DRUG therapy
*DRUG efficacy
*MEDICATION safety
*BILE acids
Subjects
Details
- Language :
- English
- ISSN :
- 20770383
- Volume :
- 6
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Journal of Clinical Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 126395390
- Full Text :
- https://doi.org/10.3390/jcm6110101