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Effects of Extracorporeal Shock Wave-Mediated Transdermal Local Anesthetic Drug Delivery on Rat Caudal Nerves.
- Source :
-
Ultrasound in Medicine & Biology . Jan2018, Vol. 44 Issue 1, p214-222. 9p. - Publication Year :
- 2018
-
Abstract
- Cavitation plays a substantial role in the clinical effects of extracorporeal shock wave therapy (ESWT). It is also generally accepted as a major mechanism in sonophoresis. To identify the enhancing effect of extracorporeal shock wave-mediated transdermal drug delivery, 24 Wistar rats were randomly assigned to four groups: (i) topical application of a eutectic mixture of local anesthetics (EMLA); (ii) 1-MHz ultrasound; (iii) ESWT pre-treatment combined with EMLA application; (iv) ESWT concurrent with EMLA application on rat tails. The degree of anesthesia was assessed using the amplitude and latency of sensory nerve action potentials within 5 min after a 60-min EMLA application. The results indicated that ESWT pre-treatment and concurrent ESWT accelerated the anesthetic effects of the EMLA cream on the tail nerve (p < 0.05). This finding might indicate that shock wave-mediated transdermal drug delivery is possible during the ESWT period. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03015629
- Volume :
- 44
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Ultrasound in Medicine & Biology
- Publication Type :
- Academic Journal
- Accession number :
- 126455795
- Full Text :
- https://doi.org/10.1016/j.ultrasmedbio.2017.09.010