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Synthesis of a tetrasaccharide repeating unit of the exopolysaccharide from Burkholderia multivorans.
- Source :
-
Journal of Carbohydrate Chemistry . 2017, Vol. 36 Issue 4-6, p189-204. 16p. - Publication Year :
- 2017
-
Abstract
- The chemical synthesis of a tetrasaccharide repeating unit of the exopolysaccharide discovered from Burkholderia multivorans with a 3-aminopropyl group linked to the glycan downstream end, α-D-Manp-(1→2)-α-D-Manp-(1→2)-3-O-methyl-α-D-Rhap-(1→3)-α-D-Rhap-O(CH2)3NH2 (1), was described. The target tetrasaccharide was achieved by both a convergent [2 + 2] and a linear glycosylation strategies. The latter synthesis was proved to be more efficient than the former due to the excellent stereocontrol of glycosylation. Furthermore, the 3-aminopropyl group in the target molecule would enable its conjugation with functional biomolecules to explore its biological applications. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 07328303
- Volume :
- 36
- Issue :
- 4-6
- Database :
- Academic Search Index
- Journal :
- Journal of Carbohydrate Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 126496972
- Full Text :
- https://doi.org/10.1080/07328303.2017.1391275