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Salvage radiotherapy for palpable, locally recurrent prostate cancer after radical prostatectomy
- Source :
-
International Journal of Radiation Oncology, Biology, Physics . Apr2004, Vol. 58 Issue 5, p1530. 6p. - Publication Year :
- 2004
-
Abstract
- : PurposeA retrospective study to evaluate the outcome of salvage radiotherapy (RT) for clinically apparent, palpable prostate cancer recurrence after radical prostatectomy (RP).: Methods and materialsForty-two patients underwent RT for clinically apparent recurrent prostate cancer after RP between 1993 and 1999. The end points and treatment variables of biochemical disease-free survival were evaluated statistically.: ResultsThe median follow-up was 4.3 years. All 42 patients experienced resolution of clinically detectable recurrence within 1 year after RT. The 5-year biochemical disease-free survival, local control, freedom from distant metastases, and overall survival rate was 27%, 94%, 82%, and 78%, respectively. The initial pathologic stage (T3 or T4; p = 0.04) and interval (<2 years from RP to RT; p = 0.01) were independent predictors of biochemical failure, and RT simulation without contrast (p = 0.05) was nearly significant on multivariate analysis. Three patients (7%) experienced chronic Grade 3 or 4 RT-related toxicity.: ConclusionSalvage prostate bed RT for clinically apparent locally recurrent prostate cancer after RP provides effective local tumor control with modest durable biochemical control. Patients irradiated with a better simulation technique were found to have a more favorable outcome. A consensus on a definition of biochemical disease-free survival after salvage RT is critical for meaningful comparison of the available data and to future progress in treating this disease process. [Copyright &y& Elsevier]
- Subjects :
- *PROSTATE cancer
*RADIOTHERAPY
*CANCER relapse
*PROSTATECTOMY
Subjects
Details
- Language :
- English
- ISSN :
- 03603016
- Volume :
- 58
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- International Journal of Radiation Oncology, Biology, Physics
- Publication Type :
- Academic Journal
- Accession number :
- 12652336
- Full Text :
- https://doi.org/10.1016/j.ijrobp.2003.09.082