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Concurrent Chemoradiotherapy in Curatively Resected Gallbladder Carcinoma: A Propensity Score-Matched Analysis.
- Source :
-
International Journal of Radiation Oncology, Biology, Physics . Jan2018, Vol. 100 Issue 1, p138-145. 8p. - Publication Year :
- 2018
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Abstract
- <bold>Purpose: </bold>To compare overall survival (OS) between patients receiving radical resection followed by concurrent chemoradiotherapy (S+CCRT) and patients receiving radical resection only (S) for advanced resectable gallbladder carcinoma (GBC).<bold>Methods and Materials: </bold>Ninety-four GBC patients with stage pT2-4, N0-1, and M0 consented to inclusion in a clinical database from June 2003 to July 2013. Patients who received S+CCRT were matched by propensity score with those who received S through nearest-neighbor matching, with a caliper width of 0.2 to ensure similar baseline characteristics between each group. The effects of CCRT on OS and disease-free survival (DFS) were evaluated with Kaplan-Meier analysis. Cox proportional hazards regression was performed on the entire cohort. Adverse effects and oncologic outcomes were assessed.<bold>Results: </bold>Seventy-eight patients with GBC (39 S+CCRT; 39 S) were matched according to propensity score; the 1-year, 3-year, and 5-year OS was 74.4%, 56.4%, and 42.4% for the S+CCRT group and 51.3%, 30.8%, and 17.9% for the S group. The median survival time was 27 months (interquartile range [IQR], 12-58 months) for the S+CCRT group versus 13 months (IQR, 5-30 months) for the S group (P=.004), with the 1-year and 3-year DFS being 59.0% versus 35.9% and 48.7% versus 13.5%, respectively, and the median DFS being 23 months (IQR, 8-57 months) versus 7 months (IQR, 4-23 months) (P=.004).<bold>Conclusions: </bold>The OS of matched patients with stage II-IVA GBC is significantly improved by CCRT. Radiation therapy combined with single-agent or dual-agent chemotherapy was feasible and well tolerated. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CHEMORADIOTHERAPY
*GALLBLADDER cancer
*PROGRESSION-free survival
*KAPLAN-Meier estimator
*CANCER patients
*ANTINEOPLASTIC agents
*CANCER-related mortality
*CANCER treatment
*CANCER
*SURGICAL excision
*GALLBLADDER tumors
*LYMPH node surgery
*MULTIVARIATE analysis
*PAIRED comparisons (Mathematics)
*PROBABILITY theory
*PROGNOSIS
*REGRESSION analysis
*TIME
*PILOT projects
*RETROSPECTIVE studies
*TUMOR treatment
Subjects
Details
- Language :
- English
- ISSN :
- 03603016
- Volume :
- 100
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- International Journal of Radiation Oncology, Biology, Physics
- Publication Type :
- Academic Journal
- Accession number :
- 126559091
- Full Text :
- https://doi.org/10.1016/j.ijrobp.2017.09.029