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Kinetics of anti-ZIKV antibodies after Zika infection using two commercial enzyme-linked immunoassays.
- Source :
-
Diagnostic Microbiology & Infectious Disease . Jan2018, Vol. 90 Issue 1, p26-30. 5p. - Publication Year :
- 2018
-
Abstract
- High performance assays are essential for the serological diagnosis of recent and past Zika virus (ZIKV) infections but few are presently available. We used two commercially available NS1 antigen-based enzyme-linked immunoassays to study the kinetics of anti-ZIKV IgM and IgG in 15 ZIKV-infected patients for up to 180 days after clinical onset. The Diapro assay detected anti-ZIKV IgM reactivity more frequently (100%) and for longer (median 53 days) than did the Euroimmun assay (60%; 13 days, P < 0.005). Both assays detected anti-ZIKV IgG reactivity 11 days after clinical onset in all subjects. ZIKV IgG reactivity decreased in 3 subjects, suggesting long-term false-negative results with the Euroimmun assay. Existing anti-Dengue antibodies seem to modify the detection of ZIKV IgG but the specificity of the immunoassays was not assessed. These enzyme-linked immunoassays were user-friendly and provided results rapidly in our hands but they need further assessment before being widely used for diagnosis or public health surveys. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 07328893
- Volume :
- 90
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Diagnostic Microbiology & Infectious Disease
- Publication Type :
- Academic Journal
- Accession number :
- 126597377
- Full Text :
- https://doi.org/10.1016/j.diagmicrobio.2017.09.001