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Comparative risk of new-onset diabetes mellitus for antihypertensive drugs: A network meta-analysis.
- Source :
-
Journal of Clinical Hypertension . Dec2017, Vol. 19 Issue 12, p1348-1356. 9p. - Publication Year :
- 2017
-
Abstract
- New-onset diabetes mellitus (NOD) refers to forms of diabetes mellitus that develop during the therapeutic processes of other diseases such as hypertension. This study has been conducted in a network meta-analysis to compare antihypertensive drugs by identifying both the advantages and disadvantages on NOD by focusing on their respective effect rates. Odd ratios and corresponding 95% confidence intervals or credible intervals were calculated within pairwise and network meta-analysis. A total of 38 articles with 224 140 patients were included to evaluate the preventive effect of hypertension drugs on NOD. From the network meta-analysis it was evident that both angiotensin-converting enzyme inhibitor as well as angiotensin receptor blocker treatments are associated with a lower risk of developing NOD compared with placebo, with ranking probabilities of 79.81% and 72.77%, respectively, while β-blockers and calcium channel blockers may significantly increase the probability of developing NOD (β-blockers: odds ratio, 2.18 [95% credible intervals: 1.36-3.50]; calcium channel blockers: odds ratio, 1.16 [95% credible intervals, 1.05-1.29]). In conclusion, angiotensin receptor blockers have an advantage over the other treatments regarding the NOD. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15246175
- Volume :
- 19
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Journal of Clinical Hypertension
- Publication Type :
- Academic Journal
- Accession number :
- 126655427
- Full Text :
- https://doi.org/10.1111/jch.13108