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Serum anti-PLA2R antibody as a diagnostic biomarker of idiopathic membranous nephropathy: The optimal cut-off value for Chinese patients.
- Source :
-
Clinica Chimica Acta . Jan2018, Vol. 476, p9-14. 6p. - Publication Year :
- 2018
-
Abstract
- Background The M-type phospholipase A2 receptor (PLA2R) is a specific target autoantigen identified in idiopathic membranous nephropathy (IMN). The autoantibody against PLA2R (anti-PLA2R) may be used to diagnose IMN. However, the appropriate diagnosis cut-off value for Chinese patients with IMN has not been established. Methods In total, 119 patients who underwent renal biopsy (57 patients with IMN and 62 patients with non-IMN glomerulonephritis) and 22 healthy individuals were recruited for our observation study from Qianfoshan Hospital between September 2011 and March 2016. The serum concentration of anti-PLA2R was measured using a quantitative enzyme-linked immunosorbent assay (ELISA). The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and receiver operating characteristic (ROC) curve of anti-PLA2R in diagnosing IMN were analysed based on the ELISA detection. Results The sensitivity, specificity, PPV, and NPV of anti-PLA2R in the diagnosis of IMN in the Chinese patients were 82.5, 75, 69.1, and 86.3% for the 2 RU/ml cut-off value; 78.9, 91.7, 86.5, and 86.5% for the 2.6 RU/ml cut-off value; 59.6, 95.2, 89.5, and 77.7% for the 14 RU/ml cut-off value; 50.9, 96.4, 90.6, and 74.3% for the 20 RU/ml cut-off value; and 47.4, 97.6, 93.1, and 73.2% for the 40 RU/ml cut-off value, respectively. The area under the ROC curve was 0.879. Conclusions The cut-off value of 2.6 RU/ml is recommended for the use of anti-PLA2R for the diagnosis of IMN in Chinese patients based on the ELISA. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00098981
- Volume :
- 476
- Database :
- Academic Search Index
- Journal :
- Clinica Chimica Acta
- Publication Type :
- Academic Journal
- Accession number :
- 126708898
- Full Text :
- https://doi.org/10.1016/j.cca.2017.11.006