Dammarane-type saponins from the leaves of Panax notoginseng and their neuroprotective effects on damaged SH-SY5Y cells.

Seven dammarane-type saponins previously undescribed (notoginsenosides Fh1-Fh7) were isolated from the aqueous extract leaves of Panax notoginseng (Burk.) F.H.Chen (Araliaceae), together with eleven known saponins. Their structures of were elucidated by spectroscopic analysis (NMR, UV, IR, ect. ), HR-ESI-MS techniques and chemical methods. Screening results indicated that compounds 4 , 5 , 12 , 13 showed moderate neuroprotective effects on H 2 O 2 -induced cellular damage in human neuroblastoma SH-SY5Y cells (10 μM). [ABSTRACT FROM AUTHOR]