SUPPRESSION OF CONTACT SENSITIZATION IN MAN BY PRIOR FEEDING OF ANTIGEN.

Small amounts of dinitrochlorohenzene (DNCB) in capsule from were fed to 63 adult male volunteers, following which these subjects and 60 control subjects were simultaneously subjected to a sensitizing series of topical applications of the same compound. After sensitization had been achieved, the level of sensitivity was inferred from a quantitative test series. Small amounts of DNCB appeared to have no effect on subsequent sensitization. When more than 20 mgm DNCB were given by mouth, however, a significant decrease in the ultimate level of sensitivity was seen. [ABSTRACT FROM AUTHOR]