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Direct regulation of IL-2 by curcumin.
- Source :
-
Biochemical & Biophysical Research Communications . Jan2018, Vol. 495 Issue 1, p300-305. 6p. - Publication Year :
- 2018
-
Abstract
- Interleukin-2 (IL-2) is a crucial growth factor for both regulatory and effector T cells. Thus, IL-2 plays a critical role in the stimulation and suppression of immune responses. Recently, anti-IL-2 antibodies (Abs) have been shown to possess strong IL-2 modulatory activities by affecting the interaction between IL-2 and IL-2 receptors. In this study, we screened an herbal library to identify a compound that regulates IL-2, which resulted in the identification of curcumin as a direct binder and inhibitor of IL-2. Curcumin is a phytochemical with well-known anti-cancer properties. In this study, curcumin mimicked or altered the binding pattern of anti-IL-2 Abs against IL-2 and remarkably inhibited the interaction of recombinant IL-2 with the IL-2 receptor α, CD25. Interestingly, curcumin neutralized the biological activities of IL-2 both in vitro and in vivo. In this report, we elucidated the unsolved mechanism of the anti-cancer effect of curcumin by identifying IL-2 as a direct molecular target. Curcumin, as a small molecule IL-2 modulator, has the potential to be used to treat IL-2 related pathologic conditions. [ABSTRACT FROM AUTHOR]
- Subjects :
- *INTERLEUKIN-2
*T cells
*CURCUMIN
*IMMUNE response
*CANCER treatment
*THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 0006291X
- Volume :
- 495
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Biochemical & Biophysical Research Communications
- Publication Type :
- Academic Journal
- Accession number :
- 126755316
- Full Text :
- https://doi.org/10.1016/j.bbrc.2017.11.039