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Expression Pattern of Individual IFNA Subtypes in Chronic HIV Infection.
- Source :
-
Journal of Interferon & Cytokine Research . Dec2017, Vol. 37 Issue 12, p541-549. 9p. - Publication Year :
- 2017
-
Abstract
- Interferon-α (IFN-α) plays an important role in HIV pathogenesis. IFN-α consists of 13 individual IFN-α subtypes, which exhibit individual antiviral and immunomodulatory activities in HIV infection. Here, we determined the expression profiles of all IFN-α subtypes in treated and treatment-naive HIV+ patients and their impact on the induction of distinct HIV restriction factors. We collected blood samples of chronic HIV+ patients, which underwent antiretroviral therapy or were treatment-naive, and determined the individual expression levels of different IFN-α subtypes and HIV restriction factors. HIV infection transiently enhanced the expression of IFNA mRNA. The IFN-α response was dominated by the most abundantly expressed subtypes IFNA4, A5, A7, and A14 in all individuals. HIV infection affected the expression pattern of the IFN-α response, in particular for IFNA2 and IFNA16, which were elevated by chronic HIV infection. Elevated expression of HIV restriction factors was observed in chronically HIV-infected patients, which partly decreased during successful antiretroviral treatment. In vitro stimulation of peripheral blood mononuclear cells revealed that IFN-α6, -α14, and -α21 were most effective in inducing the expression of HIV restriction factors. These results indicate that HIV infection induces a specific expression pattern of IFN-α subtypes, which in turn induce the expression of various HIV restriction factors. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HIV infections
*INTERFERONS
*PROTEIN expression
*IMMUNOMODULATORS
*MESSENGER RNA
Subjects
Details
- Language :
- English
- ISSN :
- 10799907
- Volume :
- 37
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Journal of Interferon & Cytokine Research
- Publication Type :
- Academic Journal
- Accession number :
- 126828516
- Full Text :
- https://doi.org/10.1089/jir.2017.0076