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Effect of HIV on the Frequency and Number of Mycobacterium tuberculosis-Specific CD4+ T Cells in Blood and Airways During Latent M. tuberculosis Infection.
- Source :
-
Journal of Infectious Diseases . 12/15/2017, Vol. 216 Issue 12, p1550-1560. 11p. - Publication Year :
- 2017
-
Abstract
- Human immunodeficiency virus type 1 (HIV) infection substantially increases the risk of developing tuberculosis. There is extensive depletion of Mycobacterium tuberculosis-specific CD4+ T cells in blood during early HIV infection, but little is known about responses in the lungs at this stage. Given that mucosal organs are a principal target for HIV-mediated CD4+ T-cell destruction, we investigated M. tuberculosis-specific responses in bronchoalveolar lavage (BAL) from persons with latent M. tuberculosis infection and untreated HIV coinfection with preserved CD4+ T-cell counts. M. tuberculosis-specific CD4+ T-cell cytokine (interferon γ, tumor necrosis factor α, and interleukin 2) responses were discordant in frequency and function between BAL and blood. Responses in BAL were 15-fold lower in HIV-infected persons as compared to uninfected persons (P = .048), whereas blood responses were 2-fold lower (P = .006). However, an increase in T cells in the airways in HIV-infected persons resulted in the overall number of M. tuberculosis-specific CD4+ T cells in BAL being similar. Our study highlights the important insights gained from studying M. tuberculosis immunity at the site of disease during HIV infection. [ABSTRACT FROM AUTHOR]
- Subjects :
- *MYCOBACTERIUM tuberculosis
*HIV infections
*T cells
*CD4 antigen
*MIXED infections
*IMMUNITY
*TUBERCULOSIS complications
*HIV infection complications
*BLOOD
*BODY fluids
*COMPARATIVE studies
*INTERFERONS
*INTERLEUKIN-2
*LUNGS
*RESEARCH methodology
*MEDICAL cooperation
*RESEARCH
*TUBERCULOSIS
*TUMOR necrosis factors
*EVALUATION research
Subjects
Details
- Language :
- English
- ISSN :
- 00221899
- Volume :
- 216
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 126949589
- Full Text :
- https://doi.org/10.1093/infdis/jix529